The Fraunhofer Institute for Experimental Software Engineering IESE in Kaiserslautern has been one of the leading research institutions in the area of software and systems engineering as well as innovation engineering for 25 years. With its applied research, the institute develops innovative solutions for designing dependable digital ecosystems and thus accelerates the economic and social benefits for its customers. Fraunhofer IESE supports companies in overcoming challenges in the areas of “Industry 4.0”, “Autonomous Systems”, “Smart Farming”, and “Digital Healthcare” and offers digital solutions for Smart Cities and Smart Regions. In over 2,000 customer projects, the institute has transferred cutting-edge research into sustainable business practices, with a current focus on the topics of “Dependable AI”, “Digital Ecosystems”, “Digital Twin” and “System Modernization”. Fraunhofer IESE is one of 76 institutes and research units of the Fraunhofer-Gesellschaft. Together, they play a key role in shaping applied research in Europe and worldwide and contribute to Germany's international competitiveness.